Compare to the active ingredients in Excedrin® Migraine. up&up Migraine Relief Caplets contains acetaminophen, aspirin (NSAID) and caffeine to help with migraine relief. up&up Migraine Relief Caplets contains the #1 neurologist recommended active ingredient combination in OTC migraine products.* up&up products are subject to the same manufacturing standards mandated by the FDA, just like the leading national brands. *In the U.S. Source: Symphony Health Solutions